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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69213
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR2
Name: estrogen receptor 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR2increases activityEXP 6480464CTDValproic Acid metabolite results in increased activity of ESR2 protein; Valproic Acid results in increased activity of ESR2 proteinPMID:23892311
ESR2multiple interactionsEXP 6480464CTDValproic Acid metabolite promotes the reaction [Estradiol results in increased activity of ESR2 protein]; Valproic Acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]PMID:15103026 PMID:23892311
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