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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69115
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1B
Name: cyclin dependent kinase inhibitor 1B
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Baffects expressionEXP 6480464CTDValproic Acid affects the expression of CDKN1B mRNAPMID:25979313
CDKN1Bdecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of CDKN1B mRNAPMID:23179753 PMID:28001369
CDKN1Bincreases expressionEXP 6480464CTDValproic Acid results in increased expression of CDKN1B proteinPMID:21737646
CDKN1Bmultiple interactionsEXP 6480464CTD[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1B mRNA; Celecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1B protein]; Valproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1B protein]PMID:17653085 PMID:21737646
CDKN1Bincreases expressionISOCdkn1b (Mus musculus)6480464CTDValproic Acid results in increased expression of CDKN1B proteinPMID:21708246
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