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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621659
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sec22a
Name: SEC22 homolog A, vesicle trafficking protein
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sec22aaffects splicingEXP 6480464CTDValproic Acid affects the splicing of SEC22A mRNA

PMID:29427782
Sec22aaffects expressionISORGD:13446366480464CTDValproic Acid affects the expression of SEC22A mRNA

PMID:25979313
Sec22aaffects expressionISORGD:15501266480464CTDValproic Acid affects the expression of SEC22A mRNA

PMID:17963808
Sec22adecreases methylationISORGD:13446366480464CTDValproic Acid results in decreased methylation of SEC22A gene

PMID:29154799
Sec22aincreases expressionISORGD:13446366480464CTDValproic Acid results in increased expression of SEC22A mRNA

PMID:24935251
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.