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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620665
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fasn
Name: fatty acid synthase
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasndecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of FASN mRNAPMID:19224547
Fasnaffects expressionISOFasn (Mus musculus)6480464CTDValproic Acid affects the expression of FASN mRNAPMID:17292431
Fasndecreases expressionISOFASN (Homo sapiens)6480464CTDValproic Acid results in decreased expression of FASN mRNAPMID:23179753 PMID:26272509 PMID:28001369 PMID:29501571 PMID:33901630
Fasndecreases expressionISOFasn (Mus musculus)6480464CTDValproic Acid results in decreased expression of FASN mRNAPMID:19136453 PMID:21427059
Fasnincreases expressionISOFASN (Homo sapiens)6480464CTDValproic Acid results in increased expression of FASN mRNA; Valproic Acid results in increased expression of FASN proteinPMID:25716160 PMID:30003287
Fasnincreases expressionISOFasn (Mus musculus)6480464CTDValproic Acid results in increased expression of FASN mRNAPMID:15345369 PMID:21427059
Fasnmultiple interactionsISOFASN (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FASN mRNA; NR1H3 protein affects the reaction [Valproic Acid results in increased expression of FASN mRNA]PMID:27188386 PMID:30003287
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