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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620660
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptpn6decreases expressionISOPTPN6 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of PTPN6 mRNAPMID:29154799
Ptpn6increases expressionISOPTPN6 (Homo sapiens)6480464CTDValproic Acid results in increased expression of PTPN6 mRNAPMID:23527032
Ptpn6increases methylationISOPTPN6 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of PTPN6 genePMID:29154799
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