GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2d4 | affects expression | ISO | Cyp2d22 (Mus musculus) | 6480464 | CTD | Valproic Acid affects the expression of CYP2D22 mRNA | PMID:17292431 | Cyp2d4 | decreases expression | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | Valproic Acid results in decreased expression of CYP2D6 mRNA | PMID:29501571 | Cyp2d4 | increases methylation | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | Valproic Acid results in increased methylation of CYP2D6 gene | PMID:29154799 | |
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