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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620211
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nrxn2
Name: neurexin 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nrxn2affects splicingEXP 6480464CTDValproic Acid affects the splicing of NRXN2 mRNAPMID:29427782
Nrxn2affects expressionISONRXN2 (Homo sapiens)6480464CTDValproic Acid affects the expression of NRXN2 mRNAPMID:25979313
Nrxn2increases methylationISONRXN2 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of NRXN2 genePMID:29154799
Nrxn2multiple interactionsISONRXN2 (Homo sapiens)6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of NRXN2 mRNAPMID:17183730
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