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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Polg
Name: DNA polymerase gamma, catalytic subunit
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Polgaffects expressionISOPolg (Mus musculus)6480464CTDValproic Acid affects the expression of POLG mRNAPMID:17292431
Polgincreases response to substanceISOPOLG (Homo sapiens)6480464CTDPOLG gene SNP results in increased susceptibility to Valproic Acid; POLG protein mutant form results in increased susceptibility to Valproic AcidPMID:18716558 PMID:20138553
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