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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619553
Species: Mus musculus
RGD Object: Gene
Symbol: Crebbp
Name: CREB binding protein
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crebbpdecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of CREBBP mRNA; Valproic Acid results in decreased expression of CREBBP proteinPMID:19136453 PMID:27381264 PMID:32445665
Crebbpmultiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Valproic Acid results in decreased expression of CREBBP protein]PMID:27381264
Crebbpaffects expressionISOCREBBP (Homo sapiens)6480464CTDValproic Acid affects the expression of CREBBP mRNAPMID:25979313
Crebbpdecreases expressionISOCREBBP (Homo sapiens)6480464CTDValproic Acid results in decreased expression of CREBBP mRNAPMID:19101580 PMID:22083351 PMID:23179753 PMID:26272509 PMID:28001369 PMID:29154799
Crebbpdecreases methylationISOCREBBP (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of CREBBP genePMID:28853863 PMID:29201983
Crebbpincreases methylationISOCREBBP (Homo sapiens)6480464CTDValproic Acid results in increased methylation of CREBBP genePMID:29154799
Crebbpmultiple interactionsISOCREBBP (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREBBP mRNAPMID:27188386
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