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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2873
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igfbp2
Name: insulin-like growth factor binding protein 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp2increases expressionEXP 6480464CTDValproic Acid results in increased expression of IGFBP2 mRNAPMID:21318169
Igfbp2affects expressionISOIgfbp2 (Mus musculus)6480464CTDValproic Acid affects the expression of IGFBP2 mRNAPMID:17292431 PMID:17963808
Igfbp2affects expressionISOIGFBP2 (Homo sapiens)6480464CTDValproic Acid affects the expression of IGFBP2 mRNAPMID:25979313
Igfbp2increases expressionISOIGFBP2 (Homo sapiens)6480464CTDValproic Acid results in increased expression of IGFBP2 mRNAPMID:19101580 PMID:23179753 PMID:26272509 PMID:29154799
Igfbp2multiple interactionsISOIGFBP2 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGFBP2 mRNAPMID:27188386
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