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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2111
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ampd3
Name: adenosine monophosphate deaminase 3
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ampd3decreases expressionISOAMPD3 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of AMPD3 mRNAPMID:29154799
Ampd3increases methylationISOAMPD3 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of AMPD3 genePMID:29154799
Ampd3multiple interactionsISOAmpd3 (Mus musculus)6480464CTDValproic Acid inhibits the reaction [Dexamethasone results in increased expression of AMPD3 mRNA]PMID:23946490
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