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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605061
Species: Homo sapiens
RGD Object: Gene
Symbol: LGR4
Name: leucine rich repeat containing G protein-coupled receptor 4
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LGR4affects expressionEXP 6480464CTDValproic Acid affects the expression of LGR4 mRNAPMID:25979313
LGR4decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of LGR4 mRNAPMID:23179753 PMID:28001369
LGR4decreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of LGR4 genePMID:29154799
LGR4multiple interactionsEXP 6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of LGR4 mRNAPMID:17183730
LGR4affects expressionISOLgr4 (Mus musculus)6480464CTDValproic Acid affects the expression of LGR4 mRNAPMID:20421339
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