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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1601773
Species: Homo sapiens
RGD Object: Gene
Symbol: TTC28
Name: tetratricopeptide repeat domain 28
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TTC28decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of TTC28 mRNAPMID:26272509 PMID:28001369
TTC28increases methylationEXP 6480464CTDValproic Acid results in increased methylation of TTC28 genePMID:29154799
TTC28multiple interactionsEXP 6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTC28 mRNAPMID:27188386
TTC28affects splicingISOTtc28 (Rattus norvegicus)6480464CTDValproic Acid affects the splicing of TTC28 mRNAPMID:29427782
TTC28decreases expressionISOTtc28 (Rattus norvegicus)6480464CTDValproic Acid results in decreased expression of TTC28 mRNAPMID:29427782
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