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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598663
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Elk1
Name: ETS transcription factor ELK1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Elk1decreases methylationISOELK1 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of ELK1 genePMID:29154799
Elk1increases activityISOELK1 (Homo sapiens)6480464CTDValproic Acid results in increased activity of ELK1 proteinPMID:15103026
Elk1multiple interactionsISOELK1 (Homo sapiens)6480464CTDU 0126 inhibits the reaction [Valproic Acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]]; U 0126 inhibits the reaction [Valproic Acid results in increased activity of ELK1 protein]; Valproic Acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]PMID:15103026
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