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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558155
Species: Mus musculus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axdecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of H2AX mRNA; Valproic Acid results in decreased expression of H2AX proteinPMID:21427059 PMID:21708246
H2axincreases expressionEXP 6480464CTDValproic Acid results in increased expression of H2AX proteinPMID:21708246
H2axaffects expressionISOH2AX (Homo sapiens)6480464CTDValproic Acid affects the expression of H2AX mRNAPMID:25979313
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