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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553791
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt2b1
Name: UDP glucuronosyltransferase 2 family, polypeptide B1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt2b1decreases expressionISOUGT2B17 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of UGT2B17 mRNAPMID:29154799
Ugt2b1decreases methylationISOUGT2B17 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of UGT2B17 genePMID:29154799
Ugt2b1increases expressionISOUgt2b1 (Rattus norvegicus)6480464CTDValproic Acid results in increased expression of UGT2B1 mRNAPMID:17381134
Ugt2b1increases glucuronidationISOUgt2b1 (Rattus norvegicus)6480464CTDUGT2B1 protein results in increased glucuronidation of Valproic AcidPMID:8302279
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