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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551856
Species: Mus musculus
RGD Object: Gene
Symbol: Unc5c
Name: unc-5 netrin receptor C
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Unc5caffects expressionISOUNC5C (Homo sapiens)6480464CTDValproic Acid affects the expression of UNC5C mRNAPMID:23179753
Unc5caffects splicingISOUnc5c (Rattus norvegicus)6480464CTDValproic Acid affects the splicing of UNC5C mRNAPMID:29427782
Unc5cdecreases expressionISOUnc5c (Rattus norvegicus)6480464CTDValproic Acid results in decreased expression of UNC5C mRNAPMID:29427782
Unc5cdecreases methylationISOUNC5C (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of UNC5C genePMID:29154799
Unc5cincreases expressionISOUNC5C (Homo sapiens)6480464CTDValproic Acid results in increased expression of UNC5C mRNAPMID:24383497 PMID:26272509 PMID:27188386
Unc5cmultiple interactionsISOUNC5C (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNAPMID:27188386
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