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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359491
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pou5f1
Name: POU class 5 homeobox 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1affects expressionISOPou5f1 (Mus musculus)6480464CTDValproic Acid affects the expression of POU5F1 mRNAPMID:27693483
Pou5f1decreases expressionISOPOU5F1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of POU5F1 mRNA; Valproic Acid results in decreased expression of POU5F1 proteinPMID:29775723 PMID:34742744 PMID:37505509
Pou5f1decreases expressionISOPou5f1 (Mus musculus)6480464CTDValproic Acid results in decreased expression of POU5F1 mRNAPMID:27237783
Pou5f1increases expressionISOPOU5F1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of POU5F1 mRNAPMID:22723015 PMID:23527032 PMID:26272509
Pou5f1multiple interactionsISOPOU5F1 (Homo sapiens)6480464CTDValproic Acid inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA]PMID:32949729
Pou5f1multiple interactionsISOPou5f1 (Mus musculus)6480464CTD[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of POU5F1 mRNAPMID:27693483
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