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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353089
Species: Homo sapiens
RGD Object: Gene
Symbol: NPC2
Name: NPC intracellular cholesterol transporter 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NPC2decreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of NPC2 genePMID:29154799
NPC2increases expressionEXP 6480464CTDValproic Acid results in increased expression of NPC2 mRNAPMID:19101580 PMID:23179753 PMID:27188386
NPC2affects expressionISONpc2 (Mus musculus)6480464CTDValproic Acid affects the expression of NPC2 mRNAPMID:17963808
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