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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317266
Species: Mus musculus
RGD Object: Gene
Symbol: Adam12
Name: ADAM metallopeptidase domain 12
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adam12affects expressionEXP 6480464CTDValproic Acid affects the expression of ADAM12 mRNAPMID:17963808
Adam12decreases expressionISOAdam12 (Rattus norvegicus)6480464CTDValproic Acid results in decreased expression of ADAM12 mRNAPMID:29427782
Adam12increases expressionISOADAM12 (Homo sapiens)6480464CTDValproic Acid results in increased expression of ADAM12 mRNAPMID:19101580
Adam12increases methylationISOADAM12 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of ADAM12 genePMID:29154799
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