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RGD ID: 1311329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Otub1
Name: OTU deubiquitinase, ubiquitin aldehyde binding 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13227236480464CTDValproic Acid results in decreased expression of OTUB1 mRNA

PMID:23179753, PMID:24935251, PMID:26272509
increases methylationISORGD:13227236480464CTDValproic Acid results in increased methylation of OTUB1 gene

multiple interactionsISORGD:13227236480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTUB1 mRNA

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.