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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spice1
Name: spindle and centriole associated protein 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:16069536480464CTDValproic Acid affects the expression of SPICE1 mRNA

PMID:25979313
decreases expressionISORGD:16069536480464CTDValproic Acid results in decreased expression of SPICE1 mRNA

PMID:23179753
increases expressionISORGD:13321736480464CTDValproic Acid results in increased expression of SPICE1 mRNA

PMID:21427059
increases methylationISORGD:16069536480464CTDValproic Acid results in increased methylation of SPICE1 gene

PMID:29154799
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.