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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310649
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grwd1
Name: glutamate-rich WD repeat containing 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grwd1affects expressionISOGrwd1 (Mus musculus)6480464CTDValproic Acid affects the expression of GRWD1 mRNAPMID:17292431
Grwd1decreases expressionISOGrwd1 (Mus musculus)6480464CTDValproic Acid results in decreased expression of GRWD1 mRNAPMID:20546886 PMID:21427059
Grwd1increases methylationISOGRWD1 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of GRWD1 genePMID:29154799
Grwd1multiple interactionsISOGRWD1 (Homo sapiens)6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of GRWD1 mRNAPMID:17183730
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