GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hk1 | decreases expression | ISO | Hk1 (Rattus norvegicus) | 6480464 | CTD | Valproic Acid results in decreased expression of HK1 mRNA | PMID:23665938 | Hk1 | increases expression | ISO | HK1 (Homo sapiens) | 6480464 | CTD | Valproic Acid results in increased expression of HK1 mRNA | PMID:23179753 PMID:24383497 PMID:24935251 PMID:26272509 PMID:27188386 | Hk1 | increases methylation | ISO | HK1 (Homo sapiens) | 6480464 | CTD | Valproic Acid results in increased methylation of HK1 gene | PMID:29154799 | Hk1 | multiple interactions | ISO | HK1 (Homo sapiens) | 6480464 | CTD | [Hydralazine co-treated with Valproic Acid] results in increased expression of HK1 mRNA; [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HK1 mRNA | PMID:17183730 PMID:27188386 | | ||||||||||||||||||||||
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