GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | STAT3 | decreases expression | EXP | | 6480464 | CTD | Curcumin results in decreased expression of STAT3 mRNA; Curcumin results in decreased expression of STAT3 protein | PMID:16959222 PMID:20816778 PMID:36352148 | STAT3 | decreases phosphorylation | EXP | | 6480464 | CTD | Curcumin results in decreased phosphorylation of STAT3 protein | PMID:19383353 | STAT3 | multiple interactions | EXP | | 6480464 | CTD | Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of STAT3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of STAT3 protein] | PMID:16959222 PMID:17666914 PMID:19383353 PMID:34233590 PMID:36352148 | STAT3 | decreases expression | ISO | Stat3 (Rattus norvegicus) | 6480464 | CTD | Curcumin results in decreased expression of STAT3 mRNA | PMID:25963729 | STAT3 | increases phosphorylation | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Curcumin results in increased phosphorylation of STAT3 protein | PMID:25822711 | STAT3 | multiple interactions | ISO | Stat3 (Rattus norvegicus) | 6480464 | CTD | Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein] | PMID:25963729 PMID:30431687 | STAT3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein] | PMID:33617879 | |
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