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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737413
Species: Homo sapiens
RGD Object: Gene
Symbol: CDH1
Name: cadherin 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDH1increases expressionEXP 6480464CTDCurcumin results in increased expression of CDH1 proteinPMID:19573523 PMID:36640941
CDH1multiple interactionsEXP 6480464CTD[Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDH1 mRNA; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in decreased expression of CDH1 protein]PMID:25656647 PMID:34233590 PMID:35487055
CDH1multiple interactionsISOCdh1 (Mus musculus)6480464CTDCurcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]PMID:26191140
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