GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GCLC | increases activity | EXP | | 6480464 | CTD | Curcumin results in increased activity of GCLC protein | PMID:10514034 | GCLC | increases expression | EXP | | 6480464 | CTD | Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA | PMID:23710286 PMID:23954767 | GCLC | multiple interactions | EXP | | 6480464 | CTD | Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA] | PMID:23954767 PMID:31521693 | GCLC | increases expression | ISO | Gclc (Mus musculus) | 6480464 | CTD | Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein | PMID:19168576 PMID:19183254 PMID:29571711 PMID:34272803 | GCLC | increases expression | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein | PMID:17602960 PMID:18299980 PMID:18332871 PMID:36305173 | GCLC | multiple interactions | ISO | Gclc (Mus musculus) | 6480464 | CTD | Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLC protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA] | PMID:29571711 PMID:34272803 PMID:35063475 PMID:35817260 | GCLC | multiple interactions | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]; Curcumin results in increased activity of [GCLC protein binds to GCLM protein] | PMID:17602960 PMID:27837179 PMID:36305173 | | ||||||||||||||||||||||
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