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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736042
Species: Homo sapiens
RGD Object: Gene
Symbol: IGFBP3
Name: insulin like growth factor binding protein 3
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGFBP3decreases expressionEXP 6480464CTDCurcumin results in decreased expression of IGFBP3 mRNAPMID:16101141
IGFBP3increases expressionEXP 6480464CTDCurcumin results in increased expression of IGFBP3 mRNAPMID:21594647
IGFBP3increases secretionEXP 6480464CTDCurcumin results in increased secretion of IGFBP3 proteinPMID:17499312
IGFBP3multiple interactionsEXP 6480464CTD[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 proteinPMID:27430728
IGFBP3decreases expressionISOIgfbp3 (Rattus norvegicus)6480464CTDCurcumin results in decreased expression of IGFBP3 mRNAPMID:18299980
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