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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69089
Species: Homo sapiens
RGD Object: Gene
Symbol: SERPINB5
Name: serpin family B member 5
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINB5increases expressionEXP 6480464CTD[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of SERPINB5 mRNA; Curcumin results in increased expression of SERPINB5 proteinPMID:17290611 PMID:19944674
SERPINB5multiple interactionsEXP 6480464CTD[Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 proteinPMID:19944674
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