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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68556
Species: Homo sapiens
RGD Object: Gene
Symbol: CCND1
Name: cyclin D1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCND1decreases expressionEXP 6480464CTDCurcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 proteinPMID:15486348 PMID:16023083 PMID:16959222 PMID:17041101 PMID:17148446 PMID:18226269 PMID:18316600 PMID:18593936 PMID:18790744 PMID:19372569 PMID:19573523 PMID:24211270 PMID:30935902 PMID:36640941
CCND1increases degradationEXP 6480464CTDCurcumin results in increased degradation of CCND1 proteinPMID:18156803
CCND1multiple interactionsEXP 6480464CTD[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]PMID:15489888 PMID:16219905 PMID:16243823 PMID:17640567 PMID:18156803 PMID:18226269 PMID:18640131 PMID:18790744 PMID:19189304 PMID:20727180 PMID:24508477 PMID:27996348 PMID:30935902 PMID:34233590 PMID:36640941
CCND1decreases expressionISOCcnd1 (Rattus norvegicus)6480464CTDCurcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 proteinPMID:17531121 PMID:17602960
CCND1decreases expressionISOCcnd1 (Mus musculus)6480464CTDCurcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 proteinPMID:15738001 PMID:17885582 PMID:18829502 PMID:19501152
CCND1increases expressionISOCcnd1 (Rattus norvegicus)6480464CTDCurcumin results in increased expression of CCND1 mRNAPMID:25963729
CCND1increases expressionISOCcnd1 (Mus musculus)6480464CTDCurcumin results in increased expression of CCND1 mRNAPMID:25822711
CCND1multiple interactionsISOCcnd1 (Rattus norvegicus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA]PMID:17531121 PMID:17602960 PMID:25963729
CCND1multiple interactionsISOCcnd1 (Mus musculus)6480464CTD[Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 proteinPMID:17440100
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