GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hif1a | decreases expression | EXP | | 6480464 | CTD | Curcumin results in decreased expression of HIF1A mRNA | PMID:21397623 | Hif1a | decreases activity | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased activity of HIF1A protein | PMID:16880289 | Hif1a | decreases expression | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Curcumin analog results in decreased expression of HIF1A mRNA; Curcumin results in decreased expression of HIF1A mRNA | PMID:18682687 PMID:26409325 | Hif1a | multiple interactions | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A protein] | PMID:23845850 | Hif1a | multiple interactions | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form]; Curcumin analog inhibits the reaction [Ionomycin promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Curcumin analog inhibits the reaction [Ionomycin results in increased activity of HIF1A protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]; Curcumin results in decreased expression of and results in decreased activity of HIF1A protein; VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein] | PMID:18682687 PMID:20554536 | | ||||||||||||||||||||||
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