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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]

PMID:25541178
increases expressionISORGD:7314426480464CTDCurcumin results in increased expression of CASP12 protein

PMID:21793155
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.