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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1decreases phosphorylationISORb1 (Mus musculus)6480464CTDCurcumin results in decreased phosphorylation of RB1 proteinPMID:15738001
Rb1decreases phosphorylationISORB1 (Homo sapiens)6480464CTDCurcumin results in decreased phosphorylation of RB1 proteinPMID:18156803 PMID:23222814
Rb1multiple interactionsISORB1 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [bisphenol A results in increased phosphorylation of RB1 protein]PMID:23222814
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