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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1increases expressionISOODC1 (Homo sapiens)6480464CTDCurcumin results in increased expression of ODC1 mRNAPMID:17198877
Odc1multiple interactionsISOOdc1 (Mus musculus)6480464CTDCurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]PMID:12628514
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