GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | affects expression | EXP | | 6480464 | CTD | Curcumin affects the expression of BAX protein | PMID:36305173 | Bax | decreases expression | EXP | | 6480464 | CTD | Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein | PMID:25963729 PMID:26612707 | Bax | increases expression | EXP | | 6480464 | CTD | Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein | PMID:17531121 | Bax | multiple interactions | EXP | | 6480464 | CTD | 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein] | PMID:15569404 PMID:17531121 PMID:20869986 PMID:23267840 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26612707 PMID:27288928 PMID:27966075 PMID:34577062 PMID:36037877 PMID:36305173 | Bax | affects localization | ISO | BAX (Homo sapiens) | 6480464 | CTD | Curcumin affects the localization of BAX protein | PMID:17332930 PMID:20605902 | Bax | decreases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein | PMID:30935902 PMID:33582110 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein | PMID:17096185 PMID:17332930 PMID:17671742 PMID:18226269 PMID:19235267 PMID:21594647 PMID:23222814 PMID:31628941 PMID:32128952 | Bax | increases response to substance | ISO | Bax (Mus musculus) | 6480464 | CTD | BAX protein results in increased susceptibility to Curcumin | PMID:17277231 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein] | PMID:17277231 PMID:28681665 PMID:35817260 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; [Doxorubicin co-treated with Curcumin] results in increased expression of BAX mRNA; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein] | PMID:18226269 PMID:19373661 PMID:20605902 PMID:23222814 PMID:27132804 PMID:27430728 PMID:27793699 PMID:30463061 PMID:30935902 PMID:31628941 PMID:32128952 | |
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