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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560340
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ercc4
Name: ERCC excision repair 4, endonuclease catalytic subunit
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ercc4multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]PMID:22228707
Ercc4decreases expressionISOERCC4 (Homo sapiens)6480464CTDCurcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 proteinPMID:22228707
Ercc4multiple interactionsISOERCC4 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein]PMID:22228707
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