Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349615
Species: Homo sapiens
RGD Object: Gene
Symbol: PECAM1
Name: platelet and endothelial cell adhesion molecule 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PECAM1affects expressionEXP 6480464CTDCurcumin affects the expression of PECAM1 proteinPMID:17960570
PECAM1multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Particulate Matter results in increased expression of PECAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of PECAM1 protein]PMID:29244817
PECAM1decreases expressionISOPecam1 (Mus musculus)6480464CTDCurcumin results in decreased expression of PECAM1 proteinPMID:17440100
PECAM1increases expressionISOPecam1 (Rattus norvegicus)6480464CTDCurcumin results in increased expression of PECAM1 proteinPMID:17960570
PECAM1multiple interactionsISOPecam1 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 protein]PMID:23845850
PECAM1multiple interactionsISOPecam1 (Mus musculus)6480464CTDGemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein]PMID:17440100
Go Back to source page   Continue to Ontology report