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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Adecreases expressionEXP 6480464CTDCurcumin results in decreased expression of HSPA1A proteinPMID:23555722
HSPA1Aincreases expressionEXP 6480464CTDCurcumin results in increased expression of HSPA1A mRNA; Curcumin results in increased expression of HSPA1A proteinPMID:23555722
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTDCurcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPA1A mRNA]PMID:26361869
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