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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315401
Species: Homo sapiens
RGD Object: Gene
Symbol: CHUK
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHUKdecreases activityEXP 6480464CTDCurcumin results in decreased activity of CHUK proteinPMID:16023083 PMID:16219905
CHUKmultiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]PMID:15129424 PMID:15489888 PMID:16219905
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