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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10776
Species: Mus musculus
RGD Object: Gene
Symbol: Igfbp5
Name: insulin-like growth factor binding protein 5
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp5multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA]PMID:18200517
Igfbp5multiple interactionsISOIGFBP5 (Homo sapiens)6480464CTD[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 proteinPMID:27430728
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