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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10691
Species: Mus musculus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1increases expressionISONr3c1 (Rattus norvegicus)6480464CTDCurcumin results in increased expression of NR3C1 mRNAPMID:17022948
Nr3c1multiple interactionsISONR3C1 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [Dexamethasone results in increased phosphorylation of NR3C1 protein]PMID:18483179
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