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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735684
Species: Mus musculus
RGD Object: Gene
Symbol: Slc31a1
Name: solute carrier family 31, member 1
Acc ID: CHEBI:39501
Term: 2,2,2-tetramine
Definition: A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Chemical ID: MESH:D014266
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc31a1increases expressionISOSlc31a1 (Rattus norvegicus)6480464CTDTrientine results in increased expression of SLC31A1 mRNAPMID:22362149
Slc31a1increases expressionISOSLC31A1 (Homo sapiens)6480464CTDTrientine results in increased expression of SLC31A1 mRNA; Trientine results in increased expression of SLC31A1 proteinPMID:22914438
Slc31a1multiple interactionsISOSLC31A1 (Homo sapiens)6480464CTD[Trientine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Trientine promotes the reaction [SLC31A1 protein results in increased uptake of Platinum]PMID:22491798 PMID:22914438
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