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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:39483
Term: sodium dichromate
Definition: An inorganic sodium salt that has formula Cr2Na2O7.
Chemical ID: MESH:C016104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1affects expressionEXP 6480464CTDsodium bichromate affects the expression of PARP1 mRNAPMID:11960910
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDsodium bichromate results in increased cleavage of PARP1 proteinPMID:28624442
Parp1increases cleavageISOParp1 (Mus musculus)6480464CTDsodium bichromate results in increased cleavage of PARP1 proteinPMID:20298709
Parp1increases expressionISOParp1 (Mus musculus)6480464CTDsodium bichromate results in increased expression of PARP1 mRNAPMID:22155349
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDFBP1 protein promotes the reaction [sodium bichromate results in increased cleavage of PARP1 protein]PMID:28624442
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTDCAT protein inhibits the reaction [sodium bichromate results in increased cleavage of PARP1 protein]; TRP53 mutant form inhibits the reaction [sodium bichromate results in increased cleavage of PARP1 protein]PMID:20298709
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