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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736886
Species: Homo sapiens
RGD Object: Gene
Symbol: HPGD
Name: 15-hydroxyprostaglandin dehydrogenase
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HPGDdecreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of HPGD mRNAPMID:27153767 PMID:32588087
HPGDmultiple interactionsISOHpgd (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HPGD mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of HPGD mRNAPMID:36331819
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