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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases activityEXP 6480464CTDperfluorooctane sulfonic acid results in increased activity of NFE2L2 proteinPMID:26548598 PMID:30114225 PMID:30203046
Nfe2l2increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of NFE2L2 mRNA; perfluorooctane sulfonic acid results in increased expression of NFE2L2 proteinPMID:26548598 PMID:33096110 PMID:36321694
Nfe2l2increases response to substanceEXP 6480464CTDNFE2L2 gene mutant form results in increased susceptibility to perfluorooctane sulfonic acidPMID:33812015
Nfe2l2multiple interactionsEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [perfluorooctane sulfonic acid results in increased expression of NFE2L2 mRNA]; [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NFE2L2 mRNA; [perfluorooctane sulfonic acid co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of NFE2L2 mRNA; Calcitriol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form promotes the reaction [perfluorooctane sulfonic acid results in increased activity of CASP3 protein]; perfluorooctane sulfonic acid inhibits the reaction [NFE2L2 protein binds to NQO1 promoter]PMID:26548598 PMID:32991729 PMID:33096110 PMID:33812015 PMID:36321694 PMID:36331819
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of NFE2L2 mRNAPMID:32790152
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of NFE2L2 mRNAPMID:35337807
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTDperfluorooctane sulfonic acid results in decreased expression of and affects the localization of and results in decreased activity of NFE2L2 proteinPMID:26844784
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of and affects the localization of and results in decreased activity of NFE2L2 proteinPMID:26844784
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