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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227
Species: Homo sapiens
RGD Object: Gene
Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR3C1decreases expressionISONr3c1 (Rattus norvegicus)6480464CTDperfluorooctane sulfonic acid results in decreased expression of NR3C1 mRNA; perfluorooctane sulfonic acid results in decreased expression of NR3C1 proteinPMID:18692542 PMID:29807116
NR3C1increases expressionISONr3c1 (Rattus norvegicus)6480464CTDperfluorooctane sulfonic acid results in increased expression of NR3C1 mRNAPMID:24218149
NR3C1multiple interactionsISONr3c1 (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of NR3C1 mRNAPMID:36331819
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