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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of CYP7A1 mRNA

PMID:16221955, PMID:18692542, PMID:19429409
decreases expressionISORGD:104586480464CTDperfluorooctane sulfonic acid results in decreased expression of CYP7A1 mRNA

PMID:19429403, PMID:20936131, PMID:21705711, PMID:23567314, PMID:26548598
decreases expressionISORGD:692106480464CTDperfluorooctane sulfonic acid results in decreased expression of CYP7A1 mRNA

PMID:27153767
multiple interactionsISORGD:104586480464CTDPPARA protein promotes the reaction [perfluorooctane sulfonic acid results in decreased expression of CYP7A1 mRNA]

PMID:20936131
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.