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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aim2
Name: absent in melanoma 2
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aim2decreases response to substanceISOAIM2 (Homo sapiens)6480464CTDAIM2 gene mutant form results in decreased susceptibility to perfluorooctane sulfonic acidPMID:34006824
Aim2decreases response to substanceISOAim2 (Mus musculus)6480464CTDAIM2 gene mutant form results in decreased susceptibility to perfluorooctane sulfonic acidPMID:34006824
Aim2multiple interactionsISOAIM2 (Homo sapiens)6480464CTDAIM2 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of CASP1 protein]; AIM2 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL1B protein]PMID:34006824
Aim2multiple interactionsISOAim2 (Mus musculus)6480464CTDAIM2 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of CASP1 protein]; AIM2 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL1B protein]PMID:34006824
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