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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595919
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a62
Name: cytochrome P450, family 3, subfamily a, polypeptide 62
Acc ID: CHEBI:39178
Term: clothianidin
Definition: An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3.
Chemical ID: MESH:C480342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a62increases expressionISORGD:13529626480464CTDclothianidin results in increased expression of CYP3A4 mRNA

PMID:32201337
Cyp3a62multiple interactionsISORGD:13529626480464CTD[clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein [clothianidin co-treated with thiacloprid] results in increased expression of CYP3A4 protein [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA

PMID:32201337
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