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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733253
Species: Homo sapiens
RGD Object: Gene
Symbol: FGR
Name: FGR proto-oncogene, Src family tyrosine kinase
Acc ID: CHEBI:39112
Term: bosutinib
Definition: An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.
Chemical ID: MESH:C471992
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FGRdecreases activityISOFgr (Rattus norvegicus)6480464CTDbosutinib results in decreased activity of FGR proteinPMID:17114238
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